Table 2.

Fit parameters of concentration- and dose-response relationships for To042 and mexiletine for antimyotonic activity in vitro and in vivo.

	In vitro		In vivo
	IC50 (μM)	nH	ED50 (mg/kg)	nH	Min (%)
To042	0.14 ± 0.02	0.9 ± 0.1	0.07 ± 0.02	1.2 ± 0.3	30.9 ± 4.4
Mexiletine	16.9 ± 2.4	1.2 ± 0.2	7.0 ± 0.02	1.2 ± 0.2	18.0 ± 7.3

Parameter values were determined from the fit of concentration– and dose-response relationships shown in Fig. 4, Fig. 5 with standard Hill equations (1), (2), respectively. The values are given together with the SE of the fit.