Table 1.

Essential evaluation of patients with Waldenström Macroglobulinemia.

Evaluation
History & physical examination
Include funduscopic examination
Laboratory studies:
Complete blood count
Complete metabolic panel
Serum immunoglobulin levels (IgA, IgG, IgM)
Serum and urine electrophoresis with immunofixation
Serum viscosity
Serum beta-2-microglobulin level
If clinically indicated:
Cryoglobulins
Cold agglutinin titer
Von Willebrand screening
24-hour urine protein quantification
Bone marrow aspiration and biopsy
Immunohistochemistry
Flow cytometry
Include testing for MYD88 L265P gene mutation
Computed tomography scans of the chest, abdomen and pelvis with IV contrast
In patients being considered for therapy