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Frequency and the position of R282W mutation. (a) The relative frequency of R282W mutation in all human cancers. Data were obtained from the Catalogue of Somatic Mutations in Cancer (COSMIC) database (October 2015 version). (b) The structure of p53 DNA-binding domain in complex with a DNA fragment, according to X-ray-determined three-dimensional structure (PDB accession number: 1tup.pdb). The Arg282 residue is located in the H2 helix structural motif.
