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. 2016 Feb 15;5(2):e193. doi: 10.1038/oncsis.2016.2

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Copyright © 2016 Macmillan Publishers Limited

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Effects of CR on IGF-1 and IGF-1R mRNA expression and growth of the CT-2A astrocytoma. For conditions a and b, tumors were implanted into the brains of C57BL/6J mice. At 10 days post tumor implantation, mice were randomly switched to either an unrestricted (UR; n=9) or CR (n=9) diet that aimed at reducing body weight by ~30%. In condition c, tumors were implanted subcutaneously and CR started at day 14; the Kaplan–Meier survival curve indicates significantly longer survival for CR compared with UR (P=0.01). Figure parts reproduced with permission from⁶⁷.