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. 2016 Feb 29;5(2):e201. doi: 10.1038/oncsis.2016.14

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Copyright © 2016 Macmillan Publishers Limited

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Apoptosis imaging in mouse tumor by P17. (a) Imaging and quantification of total FITC fluorescence in excised 4T1 tumors from mice treated with FITC-P17 for 1 h. Data are presented as means±s.d. *P<0.05, **P<0.01, ***P<0.001. (b) Histological analysis of apoptosis region in tumor tissues. The excised tumor masses were processed for TUNEL (DNA fragmentation) and cleaved caspase-3 staining after imaging. Green indicated P17; red indicated TUNEL and cleaved caspase-3; blue indicated DAPI for nuclei detection. Scale bars, 50 μm (TUNEL); 20 μm (CC3).