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. 2016 Sep 27;24(11):2012–2020. doi: 10.1038/mt.2016.161

Figure 1.

Figure 1

mRNA lipoplexes induce a potent type I IFN response in vivo. (a) Graphical scheme of the IFN-β reporter construct. The myc-tagged luciferase gene is brought under the control of the IFN-β promoter by the Cre-Lox system. (b,c) IFN-β+/Δβ-luc mice were subcutaneous (s.c.) injected with 10 µg of OVA mRNA, mRNA lipoplexes and liposomes. Luminescence was measured 6 hours postinjection. Data are shown as mean ± SD of four mice. **P < 0.001. *P < 0.05 (Mann–Whitney test). Control = 5% glucose water; liposomes = DOTAP/DOPE lipids; mRNA lipoplexes = messenger RNA complexed to liposomes. mRNA, messenger RNA; IFN, interferon, OVA, ovalbumin; SD, standard deviation.