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. 2016 Dec 13;13(12):e1002193. doi: 10.1371/journal.pmed.1002193

Fig 4. BRCA deficiency characterized by low wild-type transcript abundance defines a unique subtype of triple negative breast cancer.

Fig 4

(A) Low WT BRCA1 abundance summarizes BRCA1 deficiency through multiple types of genomic aberrations. Arrow indicates the BRCA1 deficiency threshold. (B) Low WT BRCA2 abundance summarizes BRCA2 inactivation by multiple types of genomic aberrations. Arrow indicates BRCA2 deficiency threshold. (C) Number of silent or non-silent mutations, mutation signatures, and BRCA deficiency in TCGA TNBCs. BRCA-D, BRCA-deficient; BRCA-N, BRCA-normal; CNV, copy number variation; MMR, mismatch repair; Mut, mutation; SNV, single nucleotide variant; TCGA, The Cancer Genome Atlas; TNBC, triple negative breast cancer; WT, wild-type.