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. 2016 Dec 13;13(12):e1002193. doi: 10.1371/journal.pmed.1002193

Fig 5. BRCA-deficient subtype signature identifies triple negative breast cancer patients with improved survival with anthracycline/taxane chemotherapy.

Fig 5

(A) Proportion of BRCA-D tumors among TNBC tumors in different CMB categories. (B) Overall survival of TNBC patients by BRCA deficiency status in the TCGA cohort. (C) Overall survival of TNBC patients in the TCGA cohort by predicted BRCA deficiency status using the developed gene signature (high corresponds to BRCA-D; low to BRCA-N). (D) Overall survival of TNBC patients in the METABRIC cohort by predicted BRCA deficiency status using the developed gene signature (high corresponds to BRCA-D; low to BRCA-N). p-Values are from the log-rank test. BRCA-D, BRCA-deficient; BRCA-N, BRCA-normal; CMB, clonal mutation burden; TCGA, The Cancer Genome Atlas; TNBC, triple negative breast cancer.