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. 2016 Dec 13;11(12):e0167837. doi: 10.1371/journal.pone.0167837

Fig 3. Antibiotic treatment significantly reduces cecum metabolites concentrations.

Fig 3

Antibiotic treatment significantly reduced cecum bacterial populations for the V2 regions (a) and V6 regions (b) with both WT and Ffar2-/- mice, where the copies of 16S V2 and V6 DNA copies (which reflects the amount of bacteria) was relative to the copies of mouse genomic DNA. Total metabolite levels, which includes both the SCFAs (acetate, propionate, and butyrate) and intermediates in SCFA synthesis (succinate and lactate) in cecum samples are shown from Ffar2-/- and WT mice before pregnancy (c) and at G15 (d) under control and antibiotic-treated conditions. WT, white bars; Ffar2-/-, black bars. Data are represented as mean ± SEM (*p ≤ 0.05), n = 4–8 for a-b, n = 6–8 for c-d. Data (for a-d) were compared by Student’s t-test. (*, p<0.05).