Fig 2. V-plots generated for the PLS DA derived VIP scores versus the centred and rescaled correlation coefficients.

We dichotomised the study population in 600 participants with normal LV function and 182 with subclinical diastolic LV dysfunction. VIP is the importance of each urinary fragments in the construction of the PLS factors. The correlation coefficients reflect the association of diastolic LV dysfunction with the urinary collagen fragments. Fragments associated with normal and diastolic LV dysfunction were sitting on the left and right arms, respectively (see Table 3). Fragments derived from collagen I, III, IV and V are labelled blue, red, yellow and green, respectively.