Table 1. Characteristics of 782 Participants by Category of the Diastolic LV Function.
| Characteristic | Normal | Dysfunction | p |
|---|---|---|---|
| Number in category | 600 | 182 | |
| Number of subjects (%) | |||
| Women | 298 (49.7) | 103 (56.6) | 0.10 |
| Smokers | 129 (21.5) | 29 (15.9) | 0.10 |
| Drinking alcohol | 435 (72.5) | 107 (58.8) | 0.0004 |
| Hypertension | 180 (30.0) | 147 (80.8) | <0.0001 |
| Antihypertensive treatment | 97 (53.9) | 102 (69.4) | <0.0001 |
| Diabetes mellitus | 4 (0.7) | 5 (2.8) | 0.10 |
| Mean (SD) of characteristic | |||
| Age (years) | 46.4 (13.8) | 64.2 (12.7) | <0.0001 |
| Body mass index (kg/m2) | 25.8 (4.0) | 28.6 (4.4) | <0.0001 |
| Waist-to-hip ratio | 0.86 (0.08) | 0.90 (0.08) | <0.0001 |
| Office blood pressure (mmHg) | |||
| Systolic pressure | 125.1 (15.2) | 142.2 (18.2) | <0.0001 |
| Diastolic pressure | 79.0 (9.3) | 81.5 (10.1) | 0.0021 |
| Mean arterial pressure | 94.3 (10.2) | 101.7 (10.3) | <0.0001 |
| Heart rate (beats per minute) | 60.3 (9.2) | 62.1 (11.2) | 0.053 |
| Biochemical data | |||
| Serum creatinine (μmol/L) | 82.5 (13.5) | 86.9 (20.2) | 0.0072 |
| eGFR (mL/min/1.73 m2) | 83.2 (16.1) | 72.4 (14.6) | <0.0001 |
| Total cholesterol (mmol/L) | 5.17 (0.96) | 5.51 (0.98) | <0.0001 |
| HDL cholesterol (mmol/L) | 1.44 (0.35) | 1.38 (0.35) | 0.059 |
| Total-to-HDL cholesterol ratio | 3.75 (1.01) | 4.17 (1.05) | <0.0001 |
| Plasma glucose (mmol/L) | 4.84 (0.55) | 5.25 (1.25) | <0.0001 |
| γ-Glutamyltransferase (units/L) | 22 (12–53) | 26 (13–51) | 0.013 |
| Insulin (pmol/L) | 31.0 (13.9–69.5) | 40.9 (21.0–89.6) | <0.0001 |
eGFR indicates estimated glomerular filtration rate derived by the Chronic Kidney Disease Epidemiology Collaboration equation formula. Office blood pressure was the average of five consecutive readings. Hypertension was an office blood pressure of ≥140 mmHg systolic, or ≥90 mm Hg diastolic, or use of antihypertensive drugs. For γ−glutamyltransferase and insulin reported values are geometric means (interquartile range). Diabetes mellitus was a self-reported diagnosis, a fasting glucose level of ≥7 mmol/L, or use of antidiabetic agents.