Table 3. Multivariable-adjusted associations of tissue Doppler indexes with urinary peptides.
| Urinary peptides (SD) | Collagen Type | Model 1 | p | Model 2 | p |
|---|---|---|---|---|---|
| Estimate (95% CI) | Estimate (95% CI) | ||||
| A peak | |||||
| p107460 (863) | III | –1.450 (–2.502 to –0.398) | 0.0024 | –1.453 (–2.507 to –0.398) | 0.0024 |
| p112106 (3149) | III | –1.334 (–2.378 to –0.289) | 0.006 | –1.349 (–2.401 to –0.296) | 0.0056 |
| e’ peak | |||||
| p70635 (728) | I | –0.183 (–0.350 to –0.017) | 0.025 | –0.170 (–0.335 to –0.005) | 0.041 |
| a’ peak | |||||
| p72896 (389) | I | –0.192 (–0.330 to –0.053) | 0.0024 | –0.193 (–0.332 to –0.055) | 0.002 |
| p73697 (521) | I | –0.160 (–0.298 to –0.022) | 0.016 | –0.163 (–0.300 to –0.025) | 0.013 |
| e’/a’ peak | |||||
| p77952 (1518) | I | –0.041 (–0.072 to –0.009) | 0.006 | –0.038 (–0.070 to –0.006) | 0.011 |
| E/e’ | |||||
| p72896 (289) | I | 0.164 (0.018 to 0.310) | 0.020 | 0.163 (0.017 to 0.309) | 0.022 |
| p77018 (1504) | I | 0.210 (0.067 to 0.353) | 0.0012 | 0.208 (0.065 to 0.351) | 0.0012 |
| p107460 (863) | III | –0.168 (–0.316 to –0.021) | 0.018 | –0.164 (–0.312 to –0.016) | 0.023 |
| p115491 (2362) | I | 0.162 (0.019 to 0.305) | 0.019 | 0.161 (0.018 to 0.304) | 0.020 |
Abbreviation: CI, confidence interval. All estimates were adjusted for sex, age, body mass index, mean arterial pressure, heart rate, serum total cholesterol, γ−glutamyltransferase and creatinine, plasma glucose, LVMI and treatment with diuretics, β−blockers and inhibitors of the renin-angiotensin system. Model 2 was additionally adjusted for HDL cholesterol and insulin. Estimates express the change in the dependent variable for 1-SD increase (given between parentheses) in the urinary peptide. P-values are Bonferroni adjusted.