Table 4. Serum and urinary biomarkers by category of diastolic LV function.
| Biomarkers | Unadjusted | Adjusted | ||||
|---|---|---|---|---|---|---|
| Normal | Dysfunction | p | Normal | Dysfunction | p | |
| Urine | n = 600 | n = 182 | n = 600 | n = 182 | ||
| p77018 (I) | 2751 (56) | 3162 (136) | 0.0056 | 2770 (63) | 3099 (121) | 0.020 |
| p107460 (III) | 1788 (35) | 1515 (63) | 0.0002 | 1767 (35) | 1585 (68) | 0.022 |
| p77018/p107460 (I/III) | 2.40 (0.19) | 4.15 (0.68) | 0.015 | 2.49 (0.25) | 3.87 (0.47) | 0.0013 |
| Serum | n = 565 | n = 175 | n = 565 | n = 175 | ||
| PICP, μg/L | 103.7 (1.9) | 90.8 (2.8) | 0.0002 | 100.1 (1.8) | 102.7 (3.6) | 0.54 |
| CITP, μg/L | 5.41 (0.08) | 6.05 (0.19) | 0.003 | 5.34 (0.09) | 6.26 (0.19) | <0.0001 |
| TIMP1, ng/mL | 634 (7) | 755 (16) | <0.0001 | 653 (7) | 696 (15) | 0.013 |
| PIIINP, pg/mL | 457 (175–1160) | 513 (180–1355) | 0.15 | 447 (175–1160) | 562 (180–1355) | 0.020 |
Abbreviations: PICP, carboxyterminal propeptide of procollagen I; CITP, carboxyterminal telopeptide of collagen I; TIMP-1, tissue inhibitor of the matrix metalloproteinase type 1; PIIINP, aminoterminal propeptide of procollagen III. Values are arithmetic mean (SE) or geometric mean (interquartile range). Adjustments included body mass index, serum total cholesterol, γ−glutamyltransferase and creatinine, plasma glucose, and treatment with diuretics, β−blockers and inhibitors of the renin-angiotensin system.