Table 1. Somatic mutations found in 48 patients with CLL.

Chromosome	Gene	Position	Reference	Alternative	Mutation Type	AA Change	Patient No.
1	ITPKB	226923392	G	A	nonsynonymous SNV	p.R590W	19
2	PRKD3	37543553	G	A	stopgain SNV	p.R39X	29
2	LRP1B	141459813	TCTC	-	frameshift deletion	p.2066_2067del	40
2	SF3B1	198266834	T	C	nonsynonymous SNV	p.K700E	48, 64, 65
2	SF3B1	198267361	T	C	nonsynonymous SNV	p.K666E	16
2	SF3B1	198267484	G	C	nonsynonymous SNV	p.R625G	25
3	MYD88	38182641	T	C	stoploss SNV	p.X160R	34, 62
3	GATA2	128205685	C	T	nonsynonymous SNV	p.A64T	16
3	KLHL6	183212036	T	C	nonsynonymous SNV	p.Y394C	8
3	KLHL6	183273170	G	A	nonsynonymous SNV	p.A91V	65
3	KLHL6	183273185	T	A	nonsynonymous SNV	p.H86L	6
3	KLHL6	183273188	C	T	nonsynonymous SNV	p.C85Y	23
3	KLHL6	183273189	A	G	nonsynonymous SNV	p.C85R	65
4	KIT	55604628	C	T	stopgain SNV	p.R946X	15
4	FAT4	126239804	ACAAGAATGG	-	frameshift deletion	p.746_749del	64
4	FAT4	126241813	A	T	nonsynonymous SNV	p.N1416I	64
4	FAT4	126373317	C	A	nonsynonymous SNV	p.R3716S	15
5	CSF1R	149457767	C	T	nonsynonymous SNV	p.V213M	35
6	BRD2	32945698	GAG	-	nonframeshift deletion	p.498_499del	8, 35
7	LAMB4	107703233	T	TA	frameshift insertion	p.S1090*	57
7	LAMB4	107706935	C	T	nonsynonymous SNV	p.G853S	8
7	LAMB4	107732794	G	A	nonsynonymous SNV	p.A513V	35
7	POT1	124499011	C	A	nonsynonymous SNV	p.K103N	28
7	EZH2	148506437	G	A	nonsynonymous SNV	p.A636V	41
7	EZH2	148514402	CAGCACCACTCCACTCCACATTCTCAG	-	nonframeshift deletion	p.388_397del	38
8	SCRIB	144889100	G	T	nonsynonymous SNV	p.D754E	42
9	CDKN2A	21974808	T	A	nonsynonymous SNV	p.S7C	60
9	NOTCH1	139390648	AG	-	frameshift deletion	p.P2515*fs	40, 63
9	NOTCH1	139390815	G	-	frameshift deletion	p.Q2459fs	43
9	NOTCH1	139402795	C	T	nonsynonymous SNV	p.G1072S	43
10	EGR2	64573332	C	T	nonsynonymous SNV	p.E356K	21
11	SF1	64534502	A	AGGC	nonframeshift insertion	p.484ins	65
11	ATM	108115594	C	T	stopgain SNV	p.R248X	57
11	ATM	108163400	A	T	nonsynonymous SNV	p.L1497F	64
11	ATM	108183152	A	T	nonsynonymous SNV	p.E1978V	5
11	ATM	108186757	G	A	nonsynonymous SNV	p.E2039K	48
11	ATM	108196912	T	C	nonsynonymous SNV	p.L2312P	21
11	ATM	108201089	C	G	nonsynonymous SNV	p.R2486G	63
11	ATM	108205790	AG	-	frameshift deletion	p.2702_2702del	21
11	ATM	108206579	A	G	nonsynonymous SNV	p.D2720G	42
11	ATM	108206581	G	A	nonsynonymous SNV	p.D2721N	64
11	ATM	108206666	A	T	nonsynonymous SNV	p.K2749I	19
11	ATM	108216576	C	T	nonsynonymous SNV	p.P2842L	31
11	ATM	108216601	G	T	nonsynonymous SNV	p.L2850F	26
11	ATM	108224508	A	C	nonsynonymous SNV	p.Q2896P	48
11	ATM	108235838	G	T	nonsynonymous SNV	p.W2960C	64
12	SH2B3	111856250	G	A	nonsynonymous SNV	p.E101K	31
12	SH2B3	111885306	T	TG	frameshift inserstion	p.398ins	38
13	RB1	49039195	C	T	nonsynonymous SNV	p.S758L	34
15	TCF12	57489989	A	G	nonsynonymous SNV	p.K182R	57
15	CHD2	93563337	C	T	nonsynonymous SNV	p.H1668Y	30
17	TP53	7576874	TCCAGTGGTTTCT	-	frameshift deletion	p.188_192del	20
17	TP53	7577097	C	T	nonsynonymous SNV	p.D149N	62
17	TP53	7577121	G	A	nonsynonymous SNV	p.R141C	16
17	TP53	7577511	A	G	nonsynonymous SNV	p.L125P	35
17	TP53	7577547	C	T	nonsynonymous SNV	p.G113D	33
17	TP53	7578190	T	C	nonsynonymous SNV	p.Y88C	33
17	TP53	7578208	T	C	nonsynonymous SNV	p.H82R	63
17	TP53	7578212	G	A	stopgain SNV	p.R81X	13
18	SETBP1	42643500	C	G	nonsynonymous SNV	p.P1543R	21
19	CEBPA	33792731	G	GGCGGGT	nonframeshift insertion	p.197_199ins	61
20	SAMHD1	35579956	T	-	frameshift deletion	p.D31fs	25
21	RUNX1	36259207	G	A	nonsynonymous SNV	p.P68L	51
X	ZRSR2	15818044	CT	-	frameshift deletion	p.57_58del	5
X	BCOR	39914637	A	-	frameshift deletion	p.M1523fs	43
X	BCOR	39923684	C	T	nonsynonymous SNV	p.R1118H	11
X	BCOR	39933386	CTGGGCACCTTCGC	-	frameshift deletion	p.400_405del	65
X	DDX3X	41203568	A	AAC	frameshift insertion	p.314ins	36
X	MED12	70356335	C	G	nonsynonymous SNV	p.L1744V	39
X	ZMYM3	70468137	C	T	nonsynonymous SNV	p.R617H	60
X	STAG2	123200027	C	A	nonsynonymous SNV	p.A700D	5

Abbreviations: AA, amino acid; SNV, single nucleotide variant