. 2016 Dec 13;11(12):e0168060. doi: 10.1371/journal.pone.0168060

Table 3. The 12 conserved amino acid clusters.

	Sequence	TM
Class 1	L²⁴G²⁵F²⁶AAG²⁹L³⁰P³¹TML³⁴VFNTLSVW⁴²	Segment no.1
Class 2	I⁵³G⁵⁴FASWLGLVY⁶³AFK⁶⁶WVW⁶⁹SP⁷¹MLD⁷⁴	Segment no.2
Class 3	R⁸⁷R⁸⁸SW⁹⁰LVFSQ⁹⁵	Segment no.3
Class 4	A¹²⁵F¹²⁶AS¹²⁸A¹²⁹TQ¹³¹D¹³²I¹³³AID¹³⁶A¹³⁷	Segment no.4
Class 5	Y¹⁵⁹R¹⁶⁰AAILLASAGALILA¹⁷⁴	Segment no.5
Class 6	W¹⁸⁹GLTYALFA¹⁹⁷	Segment no.6
Class 7	P³⁶⁴ITEF³⁶⁸VQRYRWQALLLL³⁸⁰GLISTY³⁸⁶RLSD³⁹⁰	Segment no.9
Class 8	G⁴⁰⁵FSKEVIASVSKVFG⁴¹⁹VLMTLIG⁴²⁶AAAG⁴³⁰G⁴³¹	Segment no.10
Class 9	SIL⁴⁴³FIGGAAS	Segment no.11
Class 10	DNFSGG⁵⁰²LAASAFVA	Segment no.12
Class 11	A⁵²²TQ⁵²⁴YA⁵²⁶MLSSTMLLLPRFIGGYSG⁵⁴⁴TMVESLG⁵⁵¹	Segment no.13
Class 12	F⁵⁵⁵FYVTAVMGIP⁵⁶⁵	Segment no.14

Note: The residues with the superscripted numbers are the conserved amino acids.