. Author manuscript; available in PMC: 2018 Feb 1.

Published in final edited form as: Hematol Oncol Clin North Am. 2017 Feb;31(1):101–111. doi: 10.1016/j.hoc.2016.08.012

Table 3. Summary of the reported sensitivity and resistance of second generation ALK inhibitors to known crizotinib resistance mutations.

ALK Secondary Mutation	Reported Sensitive Inhibitors	Reported Resistant Inhibitors
1151Tins	Alectinib³⁶	Ceritinib⁵³
L1152R	Alectinib^36,54	Ceritinib⁵⁴
C1156Y	Alectinib³⁶	Ceritinib⁵³
I1171T	Ceritinib³³	Alectinib³⁵
F1174L/V/C	Alectinib³⁶	Ceritinib³³
L1196M	Ceritinib³³ Alectinib³⁶
G1202R		Ceritinib³³ Alectinib³⁶
S1206Y	Ceritinib³³
F1245C	Ceritinib⁵⁵
G12569A	Ceritinib³³ Alectinib⁵⁶