Oncomine database analysis of association of Klotho gene expression with brain cancers. a Klotho is downregulated in glioblastoma. Class 1, normal (n=23); class 2, tumor (n=77); p=2.1×10−9. b Klotho is downregulated in oligodendroglioma. Class 1, normal (n=23); class 2, oligodendroglioma (n=50); p=2.8×10−9. c Klotho is downregulated in astrocytoma. Class 1, normal (n=23); class 2, astrocytoma (n=26); p=2×10−7