Table 1.
Baseline Demographics and Characteristics by Treatment Group.*
| Medical (N=42) | MIS+rt-PA (N=54) | P values | |
|---|---|---|---|
| Demographic variables | |||
| Age in Years: Mean (SD) | 61.1 (12.3) | 60.7 (11) | |
| Age in Years: Median (IQR) | 62 (49.5 - 73) | 60 (54 - 69) | |
| Gender: Male | 28 (66.7%) | 35 (64.8%) | |
| Race | |||
| Caucasian | 23 (54.8%) | 30 (55.6%) | |
| African American | 11 (26.2%) | 18 (33.3%) | |
| Hispanic | 5 (11.9%) | 4 (7.4%) | |
| Other | 3 (7.1%) | 2 (3.7%) | |
| Baseline variables | |||
| Diabetes | 11 (26.2%) | 14 (25.9%) | |
| History of Hypertension | 34 (81%) | 49 (90.7%) | |
| Other Cardiovascular Disease | 14 (33.3%) | 22 (40.7%) | |
| Alcohol Abuse | 7 (16.7%) | 17 (31.5%) | |
| Presentation Blood Pressure | |||
| Systolic BP (mmHg): Mean (SD) | 186.7 (34.1) | 186.4 (33.0) | |
| Diastolic BP (mmHg): Mean (SD) | 101.9 (20.4) | 106.8 (27.7) | |
| Enrollment GCS | |||
| 3–8 | 13 (31%) | 17 (31.5%) | |
| 9–12 | 12 (28.6%) | 20 (37%) | |
| 13–15 | 17 (40.5%) | 17 (31.5%) | |
| Enrollment NIHSS: Mean (SD) | 21.6 (8.9) | 22.8 (8.5) | |
| Enrollment NIHSS: Median (IQR) | 21 (17 - 27) | 22 (18 - 29) | |
| Stability CT (last CT prior to enrollment) | |||
| ICH Volume (mL): Mean (SD) | 43.1 (15.3) | 48.2 (19.6) | |
| ICH Volume (mL): Median (IQR) | 41.4 (33.2 - 50) | 43.4 (31.6 - 59.3) | |
| IVH Volume (mL): Mean (SD) | 2.4 (3.9) | 4.6 (7.7) | |
| IVH Volume (mL): Median (IQR) | 0.7 (0 - 3.1) | 0.8 (0 - 4.4) | |
| Clot Location | |||
| Lobar | 15 (35.7%) | 18 (33.3%) | |
| Deep | 27 (64.3%) | 36 (66.7%) | |
| Treatment variables | |||
| % With ICP monitoring | 10 (23.8%) | 9 (16.7%) | 0.444 |
| % Ventilated | 16 (38.1%) | 25 (46.3%) | 0.533 |
| Time from Ictus to Randomization (Days) | 1.3 (0.6) | 1.2 (0.5) | 0.174 |
| Systolic BP (mmHg): Mean (SD) | 145.3 (20.7) | 143.9 (21.1) | 0.741 |
| Diastolic BP (mmHg): Mean (SD) | 73 (14.9) | 71.2 (13.1) | 0.534 |
| Time from Randomization to Surgery (Hours) |
6.6 (7.8) | ||
| Surgery (elapsed time from symptom onset) |
|||
| ≤ 36 Hours | 31 (57.4%) | ||
| > 36 Hours | 23 (42.6%) | ||
| Number of Doses of rt-PA: Median (IQR) | 3.5 (2 - 5.8) | ||
| Days in ICU (IQR)† | 8 (5–13) | 8 (6–15) | 0.839 |
| Days to return home (IQR)‡ | 89 (54–146) | 51 (36–89) | 0.031 |
*
SD, Standard deviation; IQR, inter-quartile range. Unless otherwise specified, the values are expressed as count and % within group.
†
P=0.839 comparing medical to MIS+rt-PA.
‡
P=0.031 comparing medical to MIS+rt-PA