Table 3.
Cox proportional regression analysis for assessing the correlation of miR-125b expression in plasma with the disease-free survival of resectable osteosarcoma.
| Covariate | Univariate analysis |
Multivariate analysis |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p | HR | 95% CI | p | |
| Age (years) | 0.209 | 0.243 | ||||
| <25 | 1.000 | 1.000 | ||||
| ≥25 | 0.714 | 0.423–1.208 | 0.717 | 0.410–1.254 | ||
| Gender | 0.660 | 0.525 | ||||
| Female | 1.000 | 1.000 | ||||
| Male | 0.889 | 0.528–1.499 | 1.206 | 0.676–2.152 | ||
| Tumor location | 0.792 | 0.339 | ||||
| Tibia/femur | 1.000 | 1.000 | ||||
| Elsewhere | 1.075 | 0.628–1.839 | 0.746 | 0.410–1.359 | ||
| Tumor stage | 0.447 | 0.036 | ||||
| T1 | 1.000 | 1.000 | ||||
| T2+T3 | 1.223 | 0.728–2.054 | 1.902 | 1.042–3.472 | ||
| Histologic grade | 0.449 | 0.769 | ||||
| G1 | 1.000 | 1.000 | ||||
| G2+G3 | 1.221 | 0.728–2.047 | 1.083 | 0.635–1.846 | ||
| Metastasis | 0.484 | 0.550 | ||||
| No | 1.000 | 1.000 | ||||
| Yes | 0.785 | 0.398–1.548 | 0.807 | 0.400–1.626 | ||
| miR-125b expression | <0.001 | <0.001 | ||||
| Low | 1.000 | 1.000 | ||||
| High | 0.299 | 0.171–0.523 | 0.230 | 0.124–0.426 | ||