Skip to main content
. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: J Investig Med. 2016 Feb 12;64(3):740–744. doi: 10.1136/jim-2016-000076

Figure 2.

Figure 2

Pathways activated following binding of the TSLP cytokine to its receptor complex. CRLF2 together with the IL-7Rα chain form a cytokine receptor signaling complex activated by TSLP. Binding of TSLP stimulates downstream JAK-STAT5 and PI3K/AKT/mTOR pathway activation and subsequent expression of genes that promote cell survival and proliferation. JAK2-STAT5, Janus Kinase 2-Signal Transducer and Activator of Transcription 5; PI3K/AKT/mTOR, phosphoinositide3-kinase/protein kinase B/mechanistic target of rapomycin; TSLP, thymic stromal lymphopoietin.