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. Author manuscript; available in PMC: 2018 Jan 6.
Published in final edited form as: Neuroscience. 2016 Nov 5;340:384–397. doi: 10.1016/j.neuroscience.2016.10.064

Figure 9.

Figure 9

Schematic showing the putative intracellular signaling pathways downstream of neurotrophin receptors, p75NTR and TrkA, which lead to mechanical and thermal hyperalgesia from NGF in rat plantar hind paw, and a summary of the anti-hyperalgesic effects of the treatments used in the study. The steps that were tested experimentally are shown by solid arrows, those that are speculative shown by broken arrows. See text for details.