Fig. 4.
Auranofin (AF) is efficacious against trichomonads in vivo. (A) Adult female C57BL/6 mice were infected intravaginally with 106 Tritrichomonas foetus D1 trophozoites and the infectious load was determined in vaginal washes at the indicated times. (B) Two days after infection, a subset of mice was given daily AF (5 mg/kg) or solvent control by oral gavage for 4 days (top scheme). On the next day, live trophozoites were enumerated in vaginal washes. Data in (A) represent the mean ± standard error of the mean (n = 5–6 animals), while each data point in (B) represents an individual animal (horizontal bars are geometric means). * P < 0.01 by Wilcoxon rank-sum test. The dashed lines indicate the detection limit of the assay.