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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Free Radic Biol Med. 2016 Oct 4;101:116–128. doi: 10.1016/j.freeradbiomed.2016.10.003

Table 1.

Relative mRNA expression of representative Nrf2 target genes in WT, Nrf2flox/flox, Nrf2flox/flox::AlbCre and systemic Nrf2-disrupted mouse livers under basal (DMSO) and induced (7 mg/kg WA) conditions.

Gene Wild-type Nrf2flox/flox Nrf2flox/flox::AlbCre Nrf2-disrupted
DMSO WA DMSO WA DMSO WA DMSO WA
Nqo1 1.0±0.2 2.9±0.2* 1.6±0.6 3.1±0.3*,a 0.7±0.1 1.4±0.1b 0.1±0.02 0.2±0.02
Gclc 1.0±0.1 3.4±0.9* 1.3±0.3 7.7±2.1*,a 0.9±0.3 3.1±0.3*,b 1.7±0.4 0.6±0.2c
Sult1a1 1.0±0.2 2.4±0.8 0.9±0.2 2.7±0.8 0.8±0.3 3.5±0.7*,b 2.2±0.5 2.5±1.3
Gstp1 1.0±0.1 2.8±0.5* 0.9±0.2 4.9±1.2*,a 0.4±0.1 3.1±0.2*,b 1.7±0.5 1.3±0.6
Ugt1a1 1.0±0.3 2.2±0.3* 0.8±0.2 2.0±0.5a 0.7±0.2 1.5±0.3b 0.9±0.2 1.3±0.7
Gsta1 1.0±0.2 3.2±1.2* 0.8±0.2 7.3±2.1*,a 0.2±0.1 0.8±0.2 0.8±0.2 0.6±0.2
Gsta4 1.0±0.1 3.8±1.4* 2.3±0.7* 5.4±1.4* 0.6±0.1 1.9±0.3b 1.6±0.3 0.8±0.2
Gsr1 1.0±0.1 3.4±0.9* 0.8±0.1 4.9±1.6*,a 0.9±0.3 4.7±0.7*,b 1.1±0.5 0.9±0.5
Nrf2 1.0±0.3 4.8±2.8* 1.4±0.7 5.2±1.7*,a 0.1±0.02 0.5±0.1 ND ND

Values are mean ± SEM (n=3). p<0.05.

*

compared to WT DMSO,

a

compared to Nrf2flox/flox DMSO group,

b

compared to Nrf2flox/flox::AlbCre DMSO group,

c

compared to Nrf2-disrupted DMSO group.

ND: Not detected.