TABLE 2.
Factors Associated with Poor MDASI Interference Ratings Over Time (N = 72, Number Of Observations = 789)
| MDASI interference item | Estimate (SE) | P | |
|---|---|---|---|
| General activity | |||
| Change over time | Days from surgery (0–3) | 0.24 (0.03) | < 0.001 |
| Days from surgery (3–100) | –0.29 (0.03) | < 0.001 | |
| Risk factors | |||
| Age | –0.03 (0.01) | 0.01 | |
| ECOG PS (≥ 1 vs. 0) | 0.63 (0.26) | 0.02 | |
| Comorbidity (yes vs. no) | 1.28 (0.38) | < 0.001 | |
| Open thoracotomy vs. VATS lobectomy | 0.99 (0.22) | < 0.001 | |
| Days of hospitalization (≥ 7 vs. < 7) | 1.00 (0.26) | < 0.001 | |
| Pulmonary complications (yes vs. no) | 0.72 (0.23) | 0.002 | |
| Unscheduled clinic visit within 3 months postsurgery (yes vs. no) | 0.33 (0.16) | 0.04 | |
| Work | |||
| Change over time | Days from surgery (0–3) | 0.29 (0.03) | < 0.001 |
| Days from surgery (3–100) | –0.34 (0.04) | < 0.001 | |
| Risk factors | |||
| Age | –0.04 (0.01) | 0.01 | |
| ECOG PS (≥ 1 vs. 0) | 0.68 (0.29) | 0.02 | |
| Comorbidity (yes vs. no) | 1.33 (0.41) | 0.001 | |
| Open thoracotomy vs. VATS lobectomy | 1.73 (0.25) | < 0.001 | |
| Days of hospitalization (≥ 7 vs. < 7) | 0.94 (0.28) | < 0.001 | |
| Pulmonary complications (yes vs. no) | 0.77 (0.25) | 0.004 | |
| Unscheduled clinic visit within 3 months postsurgery (yes vs. no) | 0.57 (0.17) | 0.001 | |
| Walking | |||
| Change over time | D a y s from surgery (0–3) | 0.11 (0.03) | < 0.001 |
| Days from surgery (3–100) | –0.13 (0.03) | < 0.001 | |
| Risk factors | |||
| Open thoracotomy vs. VATS lobectomy | 0.48 (0.19) | 0.01 | |
| Baseline SF-12 physical composite score | –0.05 (0.01) | < 0.001 | |
| Pulmonary complications (yes vs. no) | 0.51 (0.20) | 0.014 | |
| Unscheduled clinic visit within 3 months postsurgery (yes vs. no) | 0.95 (0.14) | < 0.0001 | |
| Mood | |||
| Change over time | D a y s from surgery (0–3) | 0.10 (0.02) | < 0.001 |
| Days from surgery (3–100) | –0.12 (0.03) | < 0.001 | |
| Risk factors | |||
| Age | –0.03 (0.01) | 0.001 | |
| Baseline SF-12 mental composite score | –0.04 (0.01) | 0.0002 | |
| Comorbidity (yes vs. no) | 0.85 (0.30) | 0.005 | |
| Stage (II vs. I) | 0.49 (0.20) | 0.015 | |
| Open thoracotomy vs. VATS lobectomy | 0.68 (0.18) | 0.0002 | |
| Days of hospitalization (≥ 7 vs. < 7) | 0.48 (0.20) | 0.018 | |
| Pulmonary complications (yes vs. no) | 0.69 (0.19) | 0.0002 | |
| Unscheduled clinic visit within 3 months postsurgery (yes vs. no) | 0.48 (0.12) | 0.0002 | |
| Relations with others | |||
| Change over time | D a y s from surgery (0–3) | 0.07 (0.02) | 0.004 |
| Days from surgery (3–100) | –0.08 (0.02) | < 0.001 | |
| Risk factors | |||
| Age | –0.02 (0.008) | 0.03 | |
| Baseline SF-12 mental composite score | –0.03 (0.01) | 0.003 | |
| Stage (II vs. I) | 0.48 (0.19) | 0.011 | |
| Open thoracotomy vs. VATS lobectomy | 0.57 (0.16) | < 0.001 | |
| Days of hospitalization (≥ 7 vs. < 7) | 0.40 (0.18) | 0.028 | |
| Unscheduled clinic visit within 3 months postsurgery (yes vs. no) | 0.38 (0.11) | 0.0009 | |
| Enjoyment of life | |||
| Change over time | D a y s from surgery (0–3) | 0.14 (0.03) | < 0.001 |
| Days from surgery (3–100) | –0.17 (0.04) | < 0.001 | |
| Risk factors | |||
| Baseline SF-12 mental composite score | –0.04 (0.01) | 0.003 | |
| Comorbidity (yes vs. no) | 1.27 (0.36) | 0.0004 | |
| Open thoracotomy vs. VATS lobectomy | 0.93 (0.22) | < 0.0001 | |
| Days of hospitalization (≥ 7 vs. < 7) | 0.58 (0.25) | 0.019 | |
| Pulmonary complications (yes vs. no) | 0. 69 (0.22) | 0.002 | |
| Unscheduled clinic visit within 3 months postsurgery (yes vs. no) | 0.43 (0.15) | 0.005 | |
ECOG PS, Eastern Cooperative Oncology Group performance status; MDASI, MD Anderson Symptom Inventory; SE, standard error; VATS, video-assisted thoracoscopic surgery.