Table 2.
Baseline clinical characteristics and clinical data collected from most recent evaluation prior to brain donation in Parkinson's disease patients.
| Clinical data | Lewy bodies absent LC | Lewy bodies present in LC | p-value | All subjects |
|---|---|---|---|---|
| Age at death (yr) | 77.7 (9.7) | 78.4 (8.6) | 0.811 | 78.2 (8.8) |
| Age at UPDRS (yr) | 83.5 (2.1) | 74.6 (1.2) | 0.0326 | 75.3 (8.1) |
| Sex (% male) | 61.5 (0.5) | 65.6 (0.5) | 0.801 | 64.4 (0.5) |
| Age of onset (years) | 66.0 (10.1) | 60.6 (12.4) | 0.171 | 62.2 (11.9) |
| Disease Duration (years) | 15.0 (5.2) | 17.4 (6.5) | 0.241 | 16.7 (6.2) |
| UPDRS Part III: Gait | 1.7 (1.0) | 2.3 (1.2) | 0.022 | 2.1 (1.1) |
| UPDRS Part III: Postural Instability | 1.6 (1.0) | 2.1 (1.2) | 0.382 | 2.0 (1.2) |
| UPDRS Part II: Freezing | 1.2 (1.3) | 1.5 (1.4) | 0.392 | 1.4 (1.2) |
| UPDRS Part III: Generalized bradykinesia | 1.8 (1.0) | 2.1 (1.1) | 0.882 | 2.0 (1.1) |
| UPDRS Part III: Total | 36.4 (14.7) | 38.9 (10.8) | 0.531 | 38.2 (11.9) |
| TUG (seconds) | 16.8 (6.2) | 14.5 (7.4) | 0.361 | 15.2 (7.1) |
| Braak stage | 3.5 | 2.9 | 0.341 | 2.9 (1.3) |
P-values:
1
t-test of means
2
Fisher's exact test.
All data reported as mean (SD). UPDRS = Unified Parkinson's Disease Rating Scale. TUG = Timed Up-and-Go Score. LC = locus coeruleus.