Figure 2.
Upper part Examples for time courses of calculated drug concentrations in scala tympani in the 500 – 4000 Hz region after injection for different application protocols according to Dispenza et al. 2011 (55), Li et al. 2013 (78), Battaglia et al. 2008 (62), Roebuck et al. 2006 (79), and Plontke et al. 2009 (80) respectively. Lower part: Example time courses of calculated drug concentrations in scala tympani in the 500 – 4000 Hz region over the total duration of treatment for different treatment protocols: Left: daily injections for 8 days, 5 mg/ml, 0.35 ml, for 30 min application time according to Hong et al. 2009 (68). Right: 4 injections over 14 days, 5 mg/ml, 0.55 ml, for 30 min application time according to Bae et al. 2013 (54).