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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Neurobiol Aging. 2016 Sep 28;49:100–108. doi: 10.1016/j.neurobiolaging.2016.09.015

Table 3.

Comparisons of baseline subcortical white matter diffusivities and their annual changes between Parkinson’s and control subjects.

Group Comparisons
AD (×10−5 mm2/sec) RD (×10−5 mm2/sec) FA
PD Control P-Val PD Control P-Val PD Control P-Val
Overall 116.8 ± 4.2 116.1 ± 4.4 0.262 60.1 ± 3.9 59.6 ± 4.0 0.304 0.41 ± 0.02 0.42 ± 0.025 0.67
Subregions
 L. IT 112.9 ± 6.3 111.4 ± 6.6 0.088 63.5 ± 5.2 62.6 ± 5.4 0.154 0.39 ± 0.04 0.40 ± 0.04 0.53
 L. LOC 93.7 ± 7.0 92.3 ± 7.4 0.138 63.9 ± 5.8 62.9 ± 6.1 0.177 0.36 ± 0.04 0.36 ± 0.05 0.79
 L. MT 107.0 ± 5.6 105.6 ± 5.9 0.052 61.5 ± 4.9 60.0 ± 5.1 0.026 0.41 ± 0.04 0.41 ± 0.04 0.11
 L. PoC 103.5 ± 6.4 102.2 ± 6.7 0.116 61.9 ± 5.6 61.1 ± 5.8 0.317 0.39 ± 0.04 0.39 ± 0.05 0.85
 R. BSTS 109.7 ± 6.5 107.5 ± 6.8 0.011 64.7 ± 5.7 63.0 ± 6.0 0.023 0.37 ± 0.04 0.38 ± 0.04 0.30
 R. Fus 97.2 ± 6.6 95.7 ± 7.0 0.081 69.3 ± 5.4 68.0 ± 5.6 0.066 0.32 ± 0.03 0.32 ± 0.03 0.34
 R. IP 103.5 ± 7.6 102.6 ± 8.0 0.383 64.6 ± 8.1 63.3 ± 8.5 0.219 0.37 ± 0.05 0.38 ± 0.05 0.36
 R. IT 116.1 ± 8.4 114.5 ± 8.8 0.147 69.1 ± 6.3 67.5 ± 6.6 0.057 0.37 ± 0.04 0.38 ± 0.04 0.17
 R. LOF 98.5 ± 5.6 98.8 ± 5.9 0.665 66.1 ± 5.2 66.1 ± 5.5 0.950 0.32 ± 0.03 0.32 ± 0.04 0.91
 R. MT 111.1 ± 7.4 109.5 ± 7.8 0.116 65.7 ± 5.6 63.8 ± 5.9 0.011 0.38 ± 0.03 0.39 ± 0.03 0.06
 R. PoC 103.5 ± 6.4 102.2 ± 6.7 0.112 61.9 ± 5.6 61.1 ± 5.8 0.313 0.39 ± 0.04 0.39 ± 0.05 0.85
 R. SP 110.7 ± 9.6 109.5 ± 10.1 0.359 62.5 ± 8.8 60.8 ± 9.3 0.158 0.42 ± 0.05 0.43 ± 0.05 0.34
Δ AD (×10−5 mm2/sec)/y Δ RD (×10−5 mm2/sec)/y Δ FA (×10−3)/y
Overall 0.954 ± 0.639 0.976 ± 0.412 0.868 0.789 ± 0.603 0.599 ± 0.329 0.059 −2.2 ± 4.1 −0.6 ± 3.1 0.018
Subregions
 L. IT 0.288 ± 0.738 0.129 ± 0.850 0.314 0.483 ± 0.829 0.312 ± 0.676 0.279 −2.4 ± 4.9 −1.5 ± 3.5 0.381
 L. LOC 1.062 ± 0.985 1.287 ± 0.780 0.235 0.870 ± 0.847 0.777 ± 0.655 0.535 −1.5 ± 5.6 0.4 ± 4.9 0.009
 L. MT 0.549 ± 0.814 0.505 ± 0.767 0.763 0.652 ± 0.833 0.542 ± 0.556 0.424 −2.0 ± 5.2 −1.0 ± 4.9 0.226
 L. PoC 1.251 ± 0.900 1.130 ± 0.488 0.403 0.923 ± 0.872 0.617 ± 0.579 0.015 −1.1 ± 8.1 1.4 ± 5.5 0.023
 R. BSTS 1.056 ± 1.065 1.230 ± 1.001 0.443 0.699 ± 0.994 0.803 ± 0.913 0.596 −0.7 ± 5.5 −0.5 ± 6.8 0.812
 R. Fus 0.538 ± 0.953 0.770 ± 0.710 0.297 0.486 ± 0.791 0.493 ± 0.563 0.966 −0.9 ± 3.2 0.6 ± 3.6 0.017
 R. IP 1.342 ± 0.798 1.400 ± 0.835 0.761 0.944 ± 0.779 0.928 ± 0.806 0.925 −1.1 ± 4.4 −0.2 ± 3.9 0.293
 R. IT 0.812 ± 1.095 1.063 ± 0.832 0.262 0.925 ± 0.723 0.860 ± 0.677 0.679 −3.5 ± 4.1 −2.0 ± 4.6 0.026
 R. LOF 1.182 ± 1.717 1.124 ± 0.838 0.781 1.079 ± 1.540 0.841 ± 0.535 0.148 −1.9 ± 4.1 −0.1 ± 2.0 0.004
 R. MT 0.721 ± 1.080 0.922 ± 0.840 0.323 0.835 ± 0.958 0.758 ± 0.751 0.599 −3.1 ± 5.3 −1.6 ± 4.7 0.036
 R. PoC 1.295 ± 1.025 1.349 ± 0.581 0.742 0.861 ± 0.934 0.760 ± 0.687 0.476 −0.2 ± 6.9 1.4 ± 5.6 0.269
 R. SP 1.623 ± 1.025 1.709 ± 0.987 0.700 1.343 ± 0.918 1.298 ± 0.789 0.808 −4.0 ± 6.5 −2.9 ± 4.0 0.325

Bold denotes raw p values <0.05 without adjusting for multiple comparisons

Abbreviations – AD: Axial diffusivity; BST: Banks of superior temporal sulcus; Fus: Fusiform; IP: Inferior parietal; IT: Inferior temporal; L: Left; LOC: Lateral occipital; LOF: Lateral orbitofrontal; MT: Middle temporal; PoC: Postcentral; RD: Radial diffusivity; R: Right; SP: Superior parietal;