Table 5.

Associations between annual change in cortical gray matter volume and diffusion of underlying white matter.

	PD Subjects						Control Subjects
	AD		RD		FA		AD		RD		FA
	β	P-Val	β	P-Val	β	P-Val	β	P-Val	β	P-Val	β	P-Val
Cortex Total	−0.162	0.084	−0.005	0.969	−0.289	0.030	0.119	0.488	0.209	0.420	−0.150	0.490
Subregions
L. IT	−0.110	0.241	−0.164	0.246	−0.003	0.983	0.360	0.033	0.499	0.074	−0.300	0.347
L. LOC	−0.483	<0.001#	−0.597	<0.001#	0.161	0.395	−0.290	0.206	−0.366	0.142	0.053	0.835
L. MT	−0.129	0.070	−0.094	0.464	−0.184	0.202	−0.071	0.646	0.064	0.801	−0.194	0.476
L. PoC	−0.101	0.315	0.177	0.165	−0.737	<0.001#	0.155	0.326	0.114	0.593	0.027	0.923
R. BSTS	0.047	0.686	0.172	0.297	−0.283	0.125	0.257	0.196	0.171	0.462	0.139	0.574
R. Fus	−0.090	0.600	−0.037	0.828	−0.211	0.323	−0.034	0.844	−0.149	0.460	0.216	0.421
R. IP	−0.103	0.364	−0.024	0.874	−0.251	0.089	0.318	0.042	0.644	0.006	−0.582	0.004
R. IT	−0.038	0.776	0.093	0.555	−0.287	0.050	0.054	0.841	0.232	0.503	−0.430	0.127
R. LOF	0.407	0.046	0.337	0.202	0.012	0.961	−0.006	0.972	−0.003	0.987	−0.188	0.304
R. MT	−0.015	0.922	0.196	0.258	−0.413	0.018	0.192	0.463	0.095	0.780	0.003	0.991
R. PoC	−0.003	0.973	0.160	0.179	−0.444	0.012	0.138	0.282	0.190	0.270	−0.116	0.618
R. SP	−0.263	0.014	−0.190	0.206	−0.262	0.082	0.255	0.059	0.438	0.022	−0.401	0.010

Estimates and p-values in are calculated using a linear model with Parkinson’s and control subjects.

Bold denotes unadjusted p<0.05.

^#Significant after Bonferroni correction for exploration of 12 subregions and three diffusion measurements (p≤0.0013). .

Abbreviations – AD: Axial diffusivity; BST: Banks of superior temporal sulcus; Fus: Fusiform; IP: Inferior parietal; IT: Inferior temporal; L: Left; LOC: Lateral occipital; LOF: Lateral orbitofrontal; MT: Middle temporal; PoC: Postcentral; RD: Radial diffusivity; R: Right; SP: Superior parietal