Table 1.
Demographic and Clinical Data of Subjects Receiving Ketamine, Separated by Antidepressant Response at Two Weeks
| Responders at Two Weeks (n=12) mean (SD) |
Non-Responders at Two Weeks (n=81) mean (SD) |
|
|---|---|---|
| Age, years | 43.8 (12.4) | 43.7 (12.8) |
| Body mass index | 32.7 (9.0) | 28.9 (6.3) |
| Age of Onset, years | 23.9 (11.9) | 17.6 (8.8) |
| Length of Illness, years | 19.9 (10.0) | 26.0 (12.7) |
| Length of Current Depressive Episode, months |
65.8 (111.4) | 50.5 (93.6) |
| Number of Previous Episodes | 29.5 (44.0) | 30.5 (40.4) |
| Total Lifetime Medication Trials | 5.7 (3.0) | 8.0 (4.3) |
| Clinical Ratings (at baseline) | ||
| MADRS | 31.6 (3.1) | 33.0 (5.0) |
| BDI | 25.8 (6.9) | 28.1 (8.7) |
| HAM-A | 19.7 (3.4) | 21.2 (5.2) |
| Percent change in MADRS score | ||
| 230 min | −60.4 (28.6) | −31.4 (34.7) |
| 1 day | −62.5 (30.9) | −28.6 (34.5) |
| 14 days | −66.1 (14.8) | −10.0 (19.8) |
| n (%) | n (%) | |
| Education | ||
| Not College Grad | 7 (58.3) | 33 (42.3) |
| College Grad | 5 (41.7) | 45 (57.7) |
| Sex, female | 5 (41.7) | 44 (54.3) |
| Race/ethnicity, white | 11 (91.7) | 72 (91.1) |
| Diagnosis (bipolar disorder) | 2 (20.0) | 21 (36.8) |
| Lifetime History of | ||
| Suicide Attempt | 6 (50.0) | 30 (38.5) |
| Anxiety Disorder | 5 (50.0) | 30 (54.5) |
| Alcohol Abuse | 2 (16.7) | 20 (28.6) |
| Substance Abuse (non-nicotine) | 6 (50.0) | 27 (36.5) |
| Abuse | ||
| Physical | 4 (40.0) | 14 (23.0) |
| Sexual | 4 (40.0) | 13 (21.3) |
| Family History Alcohol Use Disorder, 1st Degree Relative |
6 (50.0) | 28 (35.4) |
Abbreviations: MADRS, Montgomery-Åsberg Depression Rating Scale; BDI, Beck Depression Inventory; HAM-A, Hamilton Anxiety Rating Scale