Table 2.
Downregulated pathways in spinal cord of eNAD affected horses. PBonferroni=Bonferroni adjusted P values for gene ontology enrichment analysis, with the associated pathway identification numbers
| Pathway name (ID) | # genes in Pathway | PBonferroni | Selected downregulated transcripts (fold change) |
|---|---|---|---|
| Ionotropic glutamate receptor pathway (P00037) | 34 | 1.99 × 10−5 | Glutamate receptor Ionotropic, Kainate 3 (GRIK3, −1.77)# Glutamate receptor 1 (GRIA1; −1.3)# Metabotropic glutamate receptor 3 (GRM3; −1.48) Glutamate receptor, Ionotropic, NMDA1 (GRIN1; −1.81) Vesicle-associated membrane protein 2 (VAMP2; −1.13)# |
| Synaptic vesicle trafficking pathway (P05734) | 20 | 0.001 | Regulating synaptic membrane exocystosis protein (RIMS1; −1.35) Synaptotagmin 1 (SYT1; −1.53) Synapsin-2 (SYN2; −1.48) Protein UNC-13 Homolog C (UNC13C; −1.56) Synaptogamin-12 (SYT12; −2.35) Regulating synaptic membrane exocystosis protein (RIMS2; −1.32) Synaptotagmin 7 (SYT7; −1.48) |
| Metabotropic glutamate receptor group III pathway (P0039) | 45 | 0.01 | Glutamate receptor Ionotropic, Kainate 3 (GRIK3, −1.77)# Glutamate receptor 1 (GRIA1; −1.3)# Metabotropic glutamate receptor 5 (GRM5, −1.67) |
| Cholesterol biosynthesis (P00014) | 9 | 0.02 | Squalene Monooxygenase (SQLE, −1.40) Hydroxymethylglutaryl-CoA Synthase, cytoplasmic (HMGCS1, −1.48) Diphosphomevalonate decarboxylase (MVD, −1.22) |
#
denotes transcripts that overlap between the two pathways