Table 1.
Proportion of mice with and without seizures. Distribution of maximum observed Racine seizure stage.
| Treatment | Group Size (n) | Seizure Observed (n, %) | No Seizure Observed (n, %) | Maximum Stage 3 (n, %) | Maximum Stage 4 (n, %) | Maximum Stage 5 (n, %) |
|---|---|---|---|---|---|---|
| VEH (3 × 105 PFU) | 25 | 13 (52%) | 12 (48%) | 0 (0%) | 2 (15%) | 11 (84.6) |
| MIN (50 mg/kg, b.i.d.) | 25 | 8 (32%) | 17 (68%) | 2 (25%)* | 1 (12.5%) | 5 (62.5%) |
| VEH (2.5 × 105 PFU) | 28 | 18 (64.3%) | 10 (35.7%) | 1 (5.5%) | 1 (5.5%) | 16 (88.9%) |
| MIN (50 mg/kg, q.d.) | 28 | 18 (64.3%) | 10 (35.7%) | 3 (16.7%) | 1 (5.5%) | 14 (77.8%) |
| VPA (100 mg/kg, q.d.) | 27 | 9 (33.3%)* | 18 (66.7%) | 1 (14.2%) | 0 (0%) | 6 (85.7%) |
indicates significantly different from the endpoint measurement of the VEH group in same study, p < 0.05.