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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Hum Mutat. 2016 Nov 7;38(1):112–119. doi: 10.1002/humu.23135

Table 1.

Analysis of variance (ANOVA) comparing ability of models with different SNP combinations to account for nicotine dependence (recessive model).

Variable of
interest		 ANOVA
p value		 Model 1 Model 2
rs16969968 6.0e-06 ND ~ sex + age ND ~ sex + age + rs16969968
rs880395 0.16 ND ~ sex + age ND ~ sex + age + rs880395
rs1948 0.92 ND ~ sex + age ND ~ rs1948 + sex + age
rs880395
in context of
rs16969968 		0.11 ND ~ rs16969968 + sex
+ age		 ND ~ rs16969968 + rs880395
+ sex + age
rs880395
in context of
rs1948 		0.04 ND ~ rs1948 + sex + age ND ~ rs1948 + rs880395 +
sex + age
rs1948
in context of
rs880395 		0.12 ND ~ sex + age_int +
rs880395		 ND ~ sex + age_int +
rs880395 + rs1948
rs1948
in context of
rs16969968 		0.007 ND ~ rs16969968 + sex
+ age		 ND ~ rs16969968 + rs1948 +
sex + age
rs16969968
in the context
of rs880395 		4.3e-06 ND ~ sex + age_int +
rs880395		 ND ~ sex + age_int +
rs16969968 + rs880395
rs16969968
in the context
of rs1948 		1.4e-07 ND ~ sex + age_int +
rs1948		 ND ~ sex + age_int +
rs16969968 + rs1948