Table 3.
Multivariable Cox Proportional Hazards Regression Models of Decompensated Cirrhosis for Persons with Cirrhosis and Persons without Cirrhosis at Baseline*
| Persons with cirrhosis n=11,827 |
Persons without cirrhosis n=63,978 |
||||||
|---|---|---|---|---|---|---|---|
| Adjusted HR |
95% Confidence Interval |
Adjusted HR |
95% Confidence Interval |
||||
| Male | 1.16 | 1.06 | 1.27 | 1.23 | 1.12 | 1.34 | |
| Age 18–39 | Reference | Reference | |||||
| 40–44 | 1.37 | 0.97 | 1.93 | 1.36 | 1.02 | 1.82 | |
| 45–49 | 1.68 | 1.24 | 2.26 | 2.27 | 1.78 | 2.88 | |
| 50–64 | 1.78 | 1.34 | 2.36 | 2.88 | 2.31 | 3.61 | |
| Alcoholic liver disease/alcohol abuse | 1.65 | 1.42 | 1.92 | 1.77 | 1.43 | 2.18 | |
| Obesity | 1.06 | 0.88 | 1.28 | 1.06 | 0.85 | 1.32 | |
| HBV | 1.14 | 0.76 | 1.71 | 1.45 | 0.96 | 2.18 | |
| HIV | 1.10 | 0.78 | 1.57 | 1.31 | 1.00 | 1.71 | |
| Recent treatment | 0.50 | 0.44 | 0.56 | 0.85 | 0.77 | 0.94 | |
| Diabetes | 1.42 | 1.29 | 1.56 | 1.86 | 1.69 | 2.06 | |
Interaction testing for association of diabetes and baseline cirrhosis with decompensated cirrhosis, p<0.001
Interaction testing for association of chronic hepatitis C treatment and baseline cirrhosis with decompensated cirrhosis, p<0.001
Interaction testing for association of chronic hepatitis C treatment and diabetes with decompensated cirrhosis, p=0.919 in model of persons with baseline cirrhosis and p=0.792 in model of persons without baseline cirrhosis
HR= Hazard ratio
The baseline period was defined as the first 6 months beginning on the date when the chronic hepatitis C definition was met