Skip to main content
. Author manuscript; available in PMC: 2017 Dec 30.
Published in final edited form as: Toxicology. 2016 Nov 16;374:1–9. doi: 10.1016/j.tox.2016.11.010

Fig. 3. Microglial activation in brain sub-regions of mice exposed to diesel exhaust measured by TSPO autoradiography.

Fig. 3

Autoradiography was performed on horizontal sections, using [3H]-DPA 713 as the TSPO ligand. Upper left: Representative image of horizontal brain section showing regions analyzed for TSPO autoradiography. Regions analyzed included 1) Limbic cortex, 2) Orbital cortex, 3) Somatosensory cortex, 4)Entorhinal cortex, 5) Caudate Putamen, 6) Thalamus, 7) Hippocampus, 8) Periaqueductal Grey, and 9) Cerebellum. Each region was analyzed on the right and left hemisphere. Lower left: Tendency towards increased TSPO in the cerebellum of males (p=0.0.064) and females (p=0.126). Top right and bottom right: Tendency towards increased TSPO in multiple cortical regions in males (p=0.278, limbic Cx; p=0.053, Orbital Cx; p=0.059, Somatosensory Cx; p=0.416 Entorhinal Cx), but not females. Results are the mean (± SE) of six animals for each gender and treatment.