Table 2.

Levels of pro-inflammatory cytokines IL-3 and IL-6 in olfactory bulb and hippocampus of male Gclm^+/+, Gclm^+/−, and Gclm^−/− mice following acute diesel exhaust exposure

Olfactory bulb	Gclm+/+	Gclm+/−	Gclm−/−
IL-3 (pg/ml)
FA	0.3 ± 0.1	0.5 ±0.1	0.2 ± 0.0
DE	3.8 ± 1.3**	8.3 ± 0.2***,#	5.3 ± 0.1***
IL-6 (pg/ml)
FA	1.9 ± 0.3	6.0 ± 0.3	4.0 ± 0.1
DE	32.4 ± 7.4***	403.7 ± 2.9***,###	181.9 ± 5.3***,###
Hippocampus
IL-3 (pg/ml)
FA	0.3 ± 0.1	0.5 ±0.1	0.3 ± 0.1
DE	2.6 ± 0.8**	5.5 ± 0.2***,#	2.7 ± 0.1***
IL-6 (pg/ml)
FA	1.7 ± 0.4	6.7 ± 0.1	4.0 ± 0.2
DE	30.3 ± 3.6***	314.1 ± 12.8***,###	169.2 ± 2.4***,###

Male mice of each genotype were exposed for 6 h to diesel exhaust (DE, 250–300 µg/m³) or filtered air (FA) and levels of IL-3 and IL-6 were measured in the olfactory bulb and the hippocampus. Results represent the mean of three separate animals done in triplicate. Results were analyzed for statistical significance by one-way ANOVA with Bonferroni correction for multiple comparisons; DE vs FA:

^**p<0.01;

^***p<0.001;

Gclm^+/+ vs. Gclm^+/− or Gclm^−/−:

^#p<0.05;

^##p<0.01;

^###p<0.001.