Table 3.

Effect of acute exposure to diesel exhaust on lipid peroxidation in mouse brain

Sex	Treatment	OB	HIP	CB	CX	ST
M	FA	5.0 ± 0.1	4.4 ± 0.1	3.6 ± 0.2	3.0 ± 0.2	2.2 ± 0.1
	DE	30.1 ± 1.7**	13.0 ± 0.3*	6.3 ± 0.1*	4.1 ± 0.2	6.1 ± 0.1*
	(% of FA)	602	295	175	137	277
F	FA	2.3 ± 0.1	1.1 ± 0.1	5.9 ± 0.1	4.4 ± 0.1	2.6 ± 0.1
	DE	8.4 ± 0.1*,##	2.5 ± 0.1*,#	8.8 ± 0.1*	6.7 ± 0.1	3.1 ± 0.2#
	(% of FA)	365	227	149	152	119

Levels of malonyldialdehyde (MDA, nmol/g) are shown as a measurement of lipid peroxidation. Wild-type male (M) and female (F) mice were exposed to diesel exhaust (DE; 250–300 µg/m³) or filtered air (FA) for 6 h, as described in Methods. Results represent the mean (± SE) of three animals/group analyzed in duplicate. Results were analyzed for statistical significance by one-way ANOVA with Bonferroni correction for multiple comparisons; DE vs FA:

^*p<0.05;

^**p<0.01; Female vs. male,

^#p,0.05,

^##p<0.01.

OB, olfactory bulb; HIP, hippocampus; CB, cerebellum, CX, cerebral cortex; ST, striatum.