Skip to main content
. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: J Mol Cell Cardiol. 2016 Aug 27;101:44–49. doi: 10.1016/j.yjmcc.2016.08.018

Figure 1. Overview of MAPK signaling and DUSP regulation.

Figure 1

Simplified diagram of the MAPK signaling cascade showing each step in the cascade culminating in ERK1/2, JNK1/2/3 or p38α,β,δ,γ activation, which are inactivated by specific DUSP proteins in either the cytoplasm or nucleus. Other MAPK branches not shown include MEK5-ERK5 and ERK3/4, which are less well characterized for DUSPs counter-regulation.