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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: J Mol Cell Cardiol. 2016 Oct 11;101:35–43. doi: 10.1016/j.yjmcc.2016.10.004

Figure 4. The myosin phosphatase target subunit family.

Figure 4

A) Domain alignment of MYPT family members. All members have conserved PP1c binding sequences: myosin phosphatase N-terminal extension (MyPhoNE; yellow), RVxF (blue), and ankyrin repeats (taupe). MYPT1, MYPT2, and MBS85 have a common phosphorylation site that inhibits the activity of bound catalytic subunit PP1cδ, and a C-terminal leucine zipper motif. MYPT3 and TIMAP are smaller family members with a prenylation motif (CAAX). B) Top: Ribbon and mesh diagram for the refined structure of the N-terminus of MYPT1 (residues 1-299; blue) bound to PP1cδ (burgundy) positioned with the catalytic hydrophobic groove at the top [100]. Locations of the MyPhoNE (hashtag) and RVxF (asterisk) sequences are indicated. Bottom: Table shows sequences of MyPhoNE and RVxF domains in MYPT family members.