Table 1. Ten most significant ROIs under joint variance (JVAR) test.

Greater significance and lower p-values under JVAR test implies that a ROI better characterizes S⁺ (n=37) as a group relative to S⁻ (n=442) in thickness, area, and volume measurements simultaneously. (a) One-sided F-tests for ratio of variances, with 36 and 441 degrees of freedom, between the groups were performed for thickness, area, and volume variables of each respective ROI. (b) The p-values for the JVAR test statistic $T_j=1-{\mathrm{\Pi }}_{k=1}^3(1-p_{jk})$ were generated through permutation distributions, as described in the Methods section. Significance of all 66 ROIs is provided in Supplementary Table 9. (c) FDR-adjusted p-values are over JVAR tests for 66 ROIs. (d) The left temporal pole had a FDR-adjusted p-value less than 0.05.

Rank	Region of Interest	Ratio of Variances F-testa: pjk			Joint variance testb of ℋ0;j
		Thickness	Area	Volume	Statistic Tj	p-value	FDRc
1	Left Temporal Pole d	0.044	0.014	0.002	0.0582	0.0005	0.035
2	Left Lingual	0.002	0.033	0.006	0.0403	0.0016	0.052
3	Right Middle Temporal	0.080	0.228	0.093	0.3558	0.0266	0.524
4	Left Caudal Anterior Cingulate	0.028	0.235	0.109	0.3381	0.0318	0.524
5	Right Rostral Anterior Cingulate	0.029	0.074	0.285	0.3576	0.0427	0.563
6	Left Transverse Temporal	0.031	0.053	0.385	0.4352	0.0533	0.586
7	Right Transverse Temporal	0.047	0.286	0.220	0.4686	0.0797	0.703
8	Left Entorhinal	0.065	0.063	0.372	0.4499	0.0852	0.703
9	Left Fusiform	0.286	0.256	0.244	0.5979	0.1211	0.802
10	Right Medial Orbitofrontal	0.016	0.460	0.284	0.6193	0.1409	0.802