Table 2. Lipid and lipoprotein concentrations (in mg/dL) before atorvastatin treatment and changes from baseline during atorvastatin treatment.
| Baseline | Week 4 | Week 12 | Week 24 | Week 48 | ||
|---|---|---|---|---|---|---|
| (N=28) | (N=27) | (N=26) | (N=26) | (N=26) | ||
| LDL cholesterol (mg/dL)1 | Mean (s.d.) | 161 (19) | 112 (21) | 117 (30) | 116 (27) | 117 (27) |
| Median (Min, Max) | 162 (133, 207) | 113 (74, 165) | 114 (68, 179) | 110 (84, 173) | 115 (67, 164) | |
| Mean % change (90% CI) | -30.3 (-34.6, -26.1) | -27.3 (-33.3, -21.4) | -28.0 (-32.7, -23.4) | -26.4 (-33.0, -19.7) | ||
| HDL cholesterol (mg/dL) | Mean (s.d.) | 51 (13) | 51 (11) | 52 (15) | 52 (14) | 52 (13) |
| Median (Min, Max) | 50 (31, 77) | 49 (35, 80) | 50 (25, 88) | 48 (36, 90) | 53 (30, 84) | |
| Mean % change (90% CI) | 1.8 (-2.5, 6.1) | 2.2 (-1.4, 5.8) | 3.0 (-3.1, 9.1) | 4.2 (-3.5, 11.9) | ||
| Total Cholesterol (mg/dL) | Mean (s.d.) | 237 (27) | 182 (27) | 186 (34) | 184 (32) | 185 (29) |
| Median (Min, Max) | 240 (179, 285) | 178 (135, 235) | 187 (113, 249) | 176 (142, 261) | 185 (120, 248) | |
| Mean % change (90% CI) | -23.8 (-26.8, -20.8) | -21.8 (-25.8, -17.9) | -22.5 (-26.0, -19.0) | -21.5 (-26.4, -16.6) | ||
| Non-HDL cholesterol (mg/dL) | Mean (s.d.) | 187 (26) | 130 (27) | 133 (29) | 133 (29) | 133 (30) |
| Median (Min, Max) | 186 (136, 250) | 129 (86, 185) | 132 (79, 181) | 124 (99, 192) | 130 (74, 197) | |
| Mean % change (90% CI) | -30.6 (-34.3, -26.9) | -28.4 (-32.9, -23.9) | -28.9 (-33.0, -24.8) | -28.0 (-34.0, -22.1) | ||
| Triglycerides (mg/dL) | Mean (s.d.) | 160 (89) | 136 (64) | 143 (82) | 130 (50) | 142 (103) |
| Median (Min, Max) | 124 (61, 387) | 121 (38, 272) | 126 (32, 390) | 121 (57, 250) | 111 (44, 566) | |
| Mean % change (90% CI) | -9.5 (-20.4, 1.4) | -12.2 (-19.3, -5.1) | -11.3 (-22.8, 0.3) | -12.6 (-22.5, -2.7) | ||
|
| ||||||
| Baseline | Week 12 | Week 24 | Week 48 | |||
| (N=27) | (N=24) | (N=23) | (N=24) | |||
|
| ||||||
| Apolipoprotein A1 (mg/dL) | Mean (s.d.) | 140 (22) | N/A | 142 (28) | 143 (22) | 142 (22) |
| Median (Min, Max) | 142 (91, 195) | 139 (79, 198) | 141 (101, 206) | 146 (104, 172) | ||
| Mean % change (90% CI) | 0.8 (-3.2, 4.8) | 2.4 (-2.6, 7.5) | 0.3 (-4.8, 5.4) | |||
| Apolipoprotein B (mg/dL) | Mean (s.d.) | 127 (20) | N/A | 92 (19) | 94 (19) | 95 (23) |
| Median (Min, Max) | 128 (88, 176) | 95 (58, 127) | 87 (68, 131) | 90 (58, 135) | ||
| Mean % change (90% CI) | -27.2 (-32.1, -22.4) | -25.1 (-29.6, -20.7) | -23.8 (-30.5, -17.2) | |||
| Apolipoprotein B/A1 Ratio | Mean (s.d.) | 0.93 (0.22) | N/A | 0.66 (0.15) | 0.67 (0.17) | 0.69 (0.21) |
| Median (Min, Max) | 0.92 (0.61, 1.56) | 0.70 (0.34, 0.90) | 0.67 (0.43, 1.05) | 0.65 (0.42, 1.29) | ||
| Mean % change (90% CI) | -27.3 (-32.3, -22.3) | -25.6 (-31.5, -19.7) | -23.5 (-30.1, -16.9) | |||
1
Primary efficacy measure s.d.= standard deviation CI= confidence interval