Figure 5.

Depletion of NK cells or MNPs does not significantly alter viral pathogenesis. (A) Mortality of WT mice treated i.p. with 300 µg NK1.1 antibody (Ab) or an isotype control 1 d before i.p. infection with SVN was monitored. A total of six to seven WT mice were treated and infected, divided between two independent experiments. (B) Mortality of WT and Irf2^−/− mice treated i.p. with 200 µl clodronate or PBS liposomes 3 d before i.p. infection with SVN was monitored. A total of 9–12 mice per genotype were treated and infected, divided among eight independent experiments. The p-values for survival curves were determined by the log-rank test.