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. 2016 Dec 12;213(13):2931–2947. doi: 10.1084/jem.20160303

Figure 7.

Figure 7.

B cells are protective against lethal viral neuroinvasion. (A) Mortality of B cell–deficient μMT and age-matched WT C57BL/6J mice infected i.p. with 13,000 PFU SVN was monitored for 18 d. A total of 9–16 mice per genotype were infected, divided between two independent experiments. The p-value for the survival curve was determined by the log-rank test (P = 0.0182). (B) WT and Irf2−/− mice with B cells retroorbitally adoptively transferred from WT mice were infected i.p. with 13,000 PFU SVN the day after, and their mortality was monitored for 14 d. A total of six to eight mice per genotype were infected, divided between two independent experiments. The p-value for the survival curve was determined by the log-rank test (P = 0.001). (C) WT and Irf2−/− mice were infected i.p. with 13,000 PFU SVN, and 1 d later, serum from infected WT mice (day 7 p.i.) was adoptively transferred to the animals. Their mortality was monitored for 14 d. A total of 10 mice per genotype were infected, divided among five independent experiments. The p-value for the survival curve was determined by the log-rank test.