Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Dec 12;213(13):3007–3024. doi: 10.1084/jem.20160712

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 Hayakawa et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 3. — Increased incidence of MBL/CLL/lymphoma in B1 B cells with ATA BCR. (A) Self-Thy-1 antigen-dependent CD5 induction by ATA B cells through B-1 development does not involve CD40 signal. Comparative CD5 level by mature (AA4^–) ATA B cells (ATAid⁺) in PerC in 2-mo-old ATAμκTg mice in Thy-1^−/− versus WT (Thy-1^+/+) and CD40^−/− (n = 5; mean ± SE). (B) Increased ATA B cell frequency in PBL B cells in aging ATAμTg mice. (left) ATA B increased case (marked) as MBL at 12 mo, with further B220 reduction. CD5 reduction also occurred in around half the cases of increased ATA B cells. (C) ATA B-CLL/lymphoma incidence in ATAμTg and ATAμκTg mice with or without TCL1 Tg (left). Incidence over time by ATA μκTg mice (middle). (right) Splenomegaly by TC⁺ATAμκTg mice (>90% cases) together with CLL (top), and representative total spleen cell data analysis (bottom).