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. 2016 Dec 12;213(13):3007–3024. doi: 10.1084/jem.20160712

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© 2016 Hayakawa et al.

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Figure 4. — hTCL1 expression by all B cell subsets. (left) Summary of generation of different B cell subsets in spleen through B-2 development from BM; ATA B cell subset generation in ATAμκTg mice by different levels of self-Thy-1 antigen exposure, and AGcA B cell subsets (dominantly autoreactive to mucin 2) in AGcAμκTg mice, expressing different light chain from ATA BCR. (right) 2-mo-old TC⁺ ATAμκTg (with different Thy-1 levels) and AGcAμκTg mice. CD21/CD24 staining of ATA B or AGcA B cells in spleen (both constituting the dominant B cells among total B cells) to show arrested, MZ B, or FO B dominance, and B220/CD5 staining of total (lymphocyte) spleen and PerC. AA4 (CD93) and CD23 staining was also included to confirm each subset. Marked cell subsets for cytoplasmic hTCL1 staining analysis. CD21^hiCD24^med; MZ B, CD21^medCD24^lo; FO B. Thin dotted lines in hTCL1 staining are the data from TC^– μκTg⁺ littermates as controls. Representative data of two to three samples each.