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. 2016 Dec 12;213(13):2949–2966. doi: 10.1084/jem.20160877

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© 2016 Hayano et al.

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Figure 2. — Suppression of Netrin-4 expression attenuates tactile allodynia in neuropathic pain. (A and B) Paw withdrawal thresholds of Netrin-4–mutant homozygotes (Tp/Tp; n = 10; A) and wild-type littermates (+/+; n = 13; B) to mechanical stimulation after PSL injury. (C) Relative withdrawal thresholds. (D and E) Post-injury withdrawal latencies of +/+ (open; n = 6; D) and Tp/Tp (closed; n = 7; E) animals to thermal stimuli. (F) Relative withdrawal latency. (G) Localization of a fluorescent dye–conjugated siRNA (HiLyte-488; green) and NeuN immunofluorescence (red) in the dorsal horn of the spinal cord at 2 d after intrathecal administration. Bar, 10 µm. (H) Netrin-4 mRNA expression in the spinal cord at 2 d after siRNA administration. (I) Paw withdrawal thresholds of control siRNA (closed; n = 9)– or Netrin-4 siRNA (open; n = 10)–treated animals after PSL injury. The data are presented as the mean ± SEM. *, P < 0.05; **, P < 0.01; Tukey-Kramer test. Each experiment was performed three times. contra, contralateral; ipsi, ipsilateral.