Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Dec 12;213(13):2949–2966. doi: 10.1084/jem.20160877

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 Hayano et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 3. — Tactile allodynia in a model of inflammatory pain is prevented by suppressing Netrin-4. (A and B) Paw withdrawal threshold of wild-type littermates (+/+; n = 6; A) and Netrin-4–mutant (Tp/Tp; n = 6; B) rats after CFA injections. After surgery, the +/+ rats showed decreases in the thresholds on the ipsilateral (ipsi) side (A), whereas the Tp/Tp rats did not exhibit decreases (B). contra, contralateral. (C) Comparison of the relative withdrawal thresholds between +/+ and Tp/Tp animals after CFA injections. (D) Effect of Netrin-4 siRNA on inflammation-induced tactile allodynia. The paw withdrawal threshold of the Netrin-4 siRNA–treated group (●; n = 6) was significantly increased compared with the control siRNA–treated group (○; n = 6). The data are presented as the mean ± SEM. *, P < 0.05; **, P < 0.01; Tukey-Kramer test. Each experiment was performed three times.