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. 2016 Dec 12;213(13):3075–3086. doi: 10.1084/jem.20160888

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© 2016 Muschaweckh et al.

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Figure 3. — Local antigen-dependent competition shapes the pool of skin-resident memory T cells. (A) OT-I–recipient mice were primed i.v. with MVA-OVA and immediately thereafter infected on the left (L) or right (R) ear pinna with MVA-WT or MVA-OVA, respectively (Fig. 2 A, group 3). Percentage (representative plots and top graphs, right) and absolute number (bottom graphs, right) of CD45.1⁺ OT-I cells and endogenous B8R-specific T cells among CD8⁺ T cells in the differentially infected skin 7 d (Acute) and 40 d (Memory) pi. Data were pooled from two to three independent experiments (Acute, n = 9; Memory, n = 7). (B) Percentage (representative blots and top graph) and absolute number (bottom graph) of endogenous OVA- and B8R-specific T cells among CD8⁺ T cells in MVA-WT and MVA-OVA–infected ears 40 d pi of mice as in A, but without prior transfer of OT-I. Data were pooled from two independent experiments (n = 10). (C) Fraction (representative blots and top graph) and absolute number (bottom graph) of OVA- and B8R-specific T cells among CD8⁺ T cells in MVA-OVA ΔB8R–infected versus MVA-OVA–infected skin 40 d pi. Data were pooled from two independent experiments (n = 12). Dots in graphs depict individual mice and bars show mean + SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.001 (paired Student’s t test).