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. 2016 Dec 12;213(13):3075–3086. doi: 10.1084/jem.20160888

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© 2016 Muschaweckh et al.

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Figure 4. — Local cross-competition in response to coexpressed viral antigens. (A) OT-I–recipient mice were primed i.v. with MVA-OVA and co-infected on the left ear (L) with a 1:1 mixture of mutant MVA-OVA ΔB8R (expressing OVA but not B8) and MVA-WT (lacking OVA but expressing B8) for separate delivery of OVA and B8 into the skin. For antigen (Ag) co-delivery, contralateral (right) ears (R) were co-infected with a 1:1 mix of MVA-OVA (expressing both OVA and B8) and MVA ΔB8R (lacking both OVA and B8). (B) Percentages of OT-I and endogenous B8R-specific CD8⁺ T cells in the indicated skin regions 7 d (Acute) and 40 d (Memory) pi. Data are derived from one experiment (Acute, n = 4, representative of two independent experiments) or were pooled from two independent experiments (Memory, n = 7). Dots in graphs show individual mice and horizontal bars show mean + SEM. **, P < 0.01; ***, P < 0.001 (paired Student’s t test).