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. 2016 Dec 12;213(13):2861–2870. doi: 10.1084/jem.20161135

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© 2016 Breton et al.

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Figure 3. — Human blood subsets of pre-cDCs. (a) Single-cell clustering for individual peripheral blood pre-cDCs. This analysis showed that peripheral blood pre-cDCs cluster in CD1c⁺ lineage–primed (282 single cells; blue), CD141⁺ lineage–primed (17 single cells; red), and non-DC (42 single cells; gray) populations (three samples). Shown are the top 30 genes exhibiting the strongest differential expression for each lineage-primed subset (P < 10⁻⁵; likelihood ratio test for single-cell differential expression; see the Single-cell mRNA sequencing section of Materials and methods and Table S4). (b and c) Expression of CD172a (b) and selected genes (c) in CD1c⁺ lineage–primed cells (blue), CD141⁺ lineage–primed cells (red), and non-DCs (gray) presented as violin plots (y axis, gene expression; x axis, abundance of cells expressing the gene).