Table 2:
Linear regression models between age and ROI volumes (normalized by total intracranial volume) and SPARE-AD and SPARE-BAa
| Outcome | Age | Age2 | Female | APOE ϵ4 Carriers |
|---|---|---|---|---|
| Lateral frontal volume | −0.0003900 (<.001)b | – | 0.0021720 (<.001)b | −0.0002459 (.433) |
| Lateral temporal volume | 0.0001020 (.040)b | −0.0000021 (<.001)b | 0.0003695 (.040)b | 0.0001112 (.605) |
| Medial frontal volume | −0.0001291 (<.001)b | – | 0.0010690 (<.001)b | −0.0000055 (.964) |
| Hippocampal volume | 0.0000415 (<.001)b | −0.0000005 (<.001)b | 0.0001919 (<.001)b | 0.0000118 (.649) |
| SPARE-AD | −0.0438960 (<.001)b | 0.0006549 (<.001)b | −0.1775256 (<.001)b | 0.0293579 (.582) |
| SPARE-BA | −0.1062550 (<.001)b | – | 0.6416590 (<.001)b | −0.0514570 (.452) |
a
If age2 was not significant in a model, the coefficients were recalculated after excluding. Data are coefficient (P value).
b
Significant at P < .05. Models are adjusted for education and study cohort effects. Including interaction terms between APOE status and age2, age, sex, and education one at a time to those regression models showed no significant interaction (P > .1).